Drug interactions
Ketoprofen + Nabumetone
Severity: Major
Ketoprofen and Nabumetone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together adds no meaningful extra pain relief but increases the chance of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events. The combination is generally considered therapeutic duplication.
What this interaction means in plain words
Ketoprofen and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive inhibition of cyclooxygenase with combined antiplatelet effects and loss of protective gastric and renal prostaglandins.
What to do
Avoid using two systemic NSAIDs together and keep a single agent at the lowest effective dose. If GI risk is high, add gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Ketoprofen with Nabumetone?
MediHelp rates the interaction as major. Ketoprofen and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together adds no meaningful extra pain relief but increases the chance of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events. The combination is generally considered therapeutic duplication.
How serious is the interaction between Ketoprofen and Nabumetone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two systemic NSAIDs together and keep a single agent at the lowest effective dose. If GI risk is high, add gastroprotection.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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