Drug interactions
Ketoprofen + Rivaroxaban
Severity: Major
Ketoprofen and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with rivaroxaban raises the risk of clinically significant bleeding, notably gastrointestinal bleeding. The risk applies even to short courses.
What this interaction means in plain words
Ketoprofen and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment from factor Xa inhibition and NSAID platelet inhibition plus gastrointestinal mucosal injury.
What to do
Avoid the combination where possible and use paracetamol for analgesia. If unavoidable, use the lowest NSAID dose for the shortest time with gastroprotection and monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Ketoprofen with Rivaroxaban?
MediHelp rates the interaction as major. Ketoprofen and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with rivaroxaban raises the risk of clinically significant bleeding, notably gastrointestinal bleeding. The risk applies even to short courses.
How serious is the interaction between Ketoprofen and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol for analgesia. If unavoidable, use the lowest NSAID dose for the shortest time with gastroprotection and monitor for bleeding and hemoglobin.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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