Drug interactions
Ketoprofen + Torsemide
Severity: Moderate
Ketoprofen and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and natriuretic response to loop diuretics and promote sodium and fluid retention. In volume-depleted or older patients, the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Ketoprofen and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor blood pressure, weight, edema and renal function, and increase the diuretic dose if response is reduced. Use the shortest NSAID course possible, and avoid in patients with heart failure or dehydration where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketoprofen and Torsemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Torsemide
Frequently asked questions
Can I take Ketoprofen with Torsemide?
MediHelp rates the interaction as moderate. Ketoprofen and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and natriuretic response to loop diuretics and promote sodium and fluid retention. In volume-depleted or older patients, the combination also raises the risk of acute kidney injury.
How serious is the interaction between Ketoprofen and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, edema and renal function, and increase the diuretic dose if response is reduced. Use the shortest NSAID course possible, and avoid in patients with heart failure or dehydration where feasible.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
