Drug interactions
Labetalol + Nebivolol
Severity: Major
Labetalol and Nebivolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block beta-adrenergic receptors, so using them together adds no therapeutic benefit and increases the risk of bradycardia, hypotension, and AV conduction block. Heart failure may also worsen.
What this interaction means in plain words
Labetalol and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Labetalol belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Duplicate beta-blockade produces additive pharmacodynamic effects on heart rate, conduction, and blood pressure.
What to do
Avoid combining two beta-blockers and choose a single agent. If a transition is needed, taper one before starting the other and monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Nebivolol?
MediHelp rates the interaction as major. Labetalol and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block beta-adrenergic receptors, so using them together adds no therapeutic benefit and increases the risk of bradycardia, hypotension, and AV conduction block. Heart failure may also worsen.
How serious is the interaction between Labetalol and Nebivolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two beta-blockers and choose a single agent. If a transition is needed, taper one before starting the other and monitor heart rate and blood pressure.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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