Drug interactions
Labetalol + Pilocarpine
Severity: Moderate
Labetalol and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist with some systemic absorption, and beta-blockers can add to its effects on heart rate and conduction. Conduction disturbances or bradycardia may occur, especially with oral pilocarpine.
What this interaction means in plain words
Labetalol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects on cardiac conduction from muscarinic stimulation and beta-blockade.
What to do
Monitor heart rate and watch for symptoms of bradycardia or conduction block when oral pilocarpine is used with labetalol. Pilocarpine labeling advises caution in patients taking beta-blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Labetalol with Pilocarpine?
MediHelp rates the interaction as moderate. Labetalol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist with some systemic absorption, and beta-blockers can add to its effects on heart rate and conduction. Conduction disturbances or bradycardia may occur, especially with oral pilocarpine.
How serious is the interaction between Labetalol and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and watch for symptoms of bradycardia or conduction block when oral pilocarpine is used with labetalol. Pilocarpine labeling advises caution in patients taking beta-blockers.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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