Drug interactions
Labetalol + Secobarbital
Severity: Moderate
Labetalol and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can lower exposure to drugs that are extensively metabolized. Labetalol, which is cleared by hepatic glucuronidation, may have a reduced antihypertensive effect.
What this interaction means in plain words
Labetalol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-induced hepatic enzyme induction (including glucuronidation) increases labetalol clearance.
What to do
Monitor blood pressure and heart rate when secobarbital is started or stopped. Increase the labetalol dose if the response is lost, and reduce it again after the barbiturate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Labetalol with Secobarbital?
MediHelp rates the interaction as moderate. Labetalol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can lower exposure to drugs that are extensively metabolized. Labetalol, which is cleared by hepatic glucuronidation, may have a reduced antihypertensive effect.
How serious is the interaction between Labetalol and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when secobarbital is started or stopped. Increase the labetalol dose if the response is lost, and reduce it again after the barbiturate is withdrawn.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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