Drug interactions
Labetalol + Treprostinil
Severity: Minor
Labetalol and Treprostinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and labetalol lowers blood pressure through alpha- and beta-blockade. Used together they can produce additive hypotension, although the effect is usually modest.
What this interaction means in plain words
Labetalol and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Labetalol belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilatory and blood pressure lowering effects.
What to do
Monitor blood pressure and heart rate when starting or titrating either drug, and reduce the dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Labetalol with Treprostinil?
MediHelp rates the interaction as minor. Labetalol and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Treprostinil is a potent vasodilator, and labetalol lowers blood pressure through alpha- and beta-blockade. Used together they can produce additive hypotension, although the effect is usually modest.
How serious is the interaction between Labetalol and Treprostinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating either drug, and reduce the dose if symptomatic hypotension occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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