Drug interactions
Labetalol + Umeclidinium-vilanterol
Severity: Major
Labetalol and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol is a non-selective beta blocker with alpha-blocking activity and can block the bronchodilator effect of vilanterol. In patients with COPD or asthma this may reduce bronchodilator efficacy and provoke bronchospasm.
What this interaction means in plain words
Labetalol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Labetalol belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors in the airways.
What to do
Avoid in patients with reactive airway disease where possible. If a beta blocker is needed, choose a cardioselective agent at the lowest effective dose and monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Labetalol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol is a non-selective beta blocker with alpha-blocking activity and can block the bronchodilator effect of vilanterol. In patients with COPD or asthma this may reduce bronchodilator efficacy and provoke bronchospasm.
How serious is the interaction between Labetalol and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with reactive airway disease where possible. If a beta blocker is needed, choose a cardioselective agent at the lowest effective dose and monitor respiratory function.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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