Drug interactions
Lacosamide + Larotrectinib
Severity: Minor
Lacosamide and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor in vitro, so it may slightly raise lacosamide levels. Given the minor role of CYP3A4 in lacosamide clearance, a clinically important effect is unlikely.
What this interaction means in plain words
Lacosamide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition reducing a minor lacosamide clearance pathway.
What to do
No routine adjustment is needed; monitor tolerability, especially dizziness and ataxia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Larotrectinib
Frequently asked questions
Can I take Lacosamide with Larotrectinib?
MediHelp rates the interaction as minor. Lacosamide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor in vitro, so it may slightly raise lacosamide levels. Given the minor role of CYP3A4 in lacosamide clearance, a clinically important effect is unlikely.
How serious is the interaction between Lacosamide and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor tolerability, especially dizziness and ataxia.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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