Drug interactions
Lacosamide + Orlistat
Severity: Minor
Lacosamide and Orlistat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat has been associated with reduced levels of some antiepileptics and breakthrough seizures. Lacosamide is well absorbed and not lipophilic-dependent, so an effect is theoretical.
What this interaction means in plain words
Lacosamide and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Orlistat belongs to Miscellaneous.
Why it happens
Possible reduced gastrointestinal absorption; not established for lacosamide.
What to do
Monitor seizure control when orlistat is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Lacosamide with Orlistat?
MediHelp rates the interaction as minor. Lacosamide and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orlistat has been associated with reduced levels of some antiepileptics and breakthrough seizures. Lacosamide is well absorbed and not lipophilic-dependent, so an effect is theoretical.
How serious is the interaction between Lacosamide and Orlistat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control when orlistat is started or stopped.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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