Drug interactions
Lamotrigine + Medroxyprogesterone
Severity: Minor
Lamotrigine and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The reduction in lamotrigine concentrations is attributed to the estrogen in combined contraceptives. Medroxyprogesterone alone is not known to meaningfully change lamotrigine exposure.
What this interaction means in plain words
Lamotrigine and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamotrigine belongs to Central Nervous System; Medroxyprogesterone belongs to Endocrine.
Why it happens
Progestins alone have no established effect on lamotrigine glucuronidation; the effect is estrogen-mediated.
What to do
No routine dose adjustment is needed. If seizure control changes, check lamotrigine levels and consider other causes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lamotrigine
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Lamotrigine with Medroxyprogesterone?
MediHelp rates the interaction as minor. Lamotrigine and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The reduction in lamotrigine concentrations is attributed to the estrogen in combined contraceptives. Medroxyprogesterone alone is not known to meaningfully change lamotrigine exposure.
How serious is the interaction between Lamotrigine and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. If seizure control changes, check lamotrigine levels and consider other causes.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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