Drug interactions
Lamotrigine + Metoclopramide
Severity: Minor
Lamotrigine and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may cause dizziness and drowsiness, and metoclopramide has been associated with seizures in predisposed patients. No significant pharmacokinetic interaction is established.
What this interaction means in plain words
Lamotrigine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamotrigine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS effects; possible lowering of seizure threshold by metoclopramide.
What to do
Monitor for sedation and any change in seizure frequency. Prefer short metoclopramide courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Metoclopramide?
MediHelp rates the interaction as minor. Lamotrigine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs may cause dizziness and drowsiness, and metoclopramide has been associated with seizures in predisposed patients. No significant pharmacokinetic interaction is established.
How serious is the interaction between Lamotrigine and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and any change in seizure frequency. Prefer short metoclopramide courses.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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