Drug interactions
Lamotrigine + Vilazodone
Severity: Minor
Lamotrigine and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, dizziness and impaired coordination. Used together, psychomotor effects may be somewhat greater, though this combination is common in bipolar depression and is usually well tolerated.
What this interaction means in plain words
Lamotrigine and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamotrigine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Mild additive CNS effects; no significant pharmacokinetic interaction is established.
What to do
No dose change is usually needed; monitor for sedation or dizziness, especially when starting or increasing either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Vilazodone?
MediHelp rates the interaction as minor. Lamotrigine and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness, dizziness and impaired coordination. Used together, psychomotor effects may be somewhat greater, though this combination is common in bipolar depression and is usually well tolerated.
How serious is the interaction between Lamotrigine and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for sedation or dizziness, especially when starting or increasing either drug.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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