Drug interactions
Lanreotide + Metformin-sitagliptin
Severity: Moderate
Lanreotide and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanreotide suppresses insulin, glucagon and growth hormone secretion, which can cause either hypo- or hyperglycemia. Glycemic control in patients on metformin and sitagliptin may therefore change.
What this interaction means in plain words
Lanreotide and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lanreotide belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Somatostatin analogue inhibition of insulin and counter-regulatory hormone secretion alters glucose homeostasis.
What to do
Monitor blood glucose when starting lanreotide or changing the dose, and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Lanreotide
- Lanreotide + Quinidine Major
- Alogliptin-metformin + Lanreotide Moderate
- Canagliflozin-metformin + Lanreotide Moderate
- Cyclosporin + Lanreotide Moderate
- Dapagliflozin-metformin + Lanreotide Moderate
- Empagliflozin-metformin + Lanreotide Moderate
Frequently asked questions
Can I take Lanreotide with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Lanreotide and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lanreotide suppresses insulin, glucagon and growth hormone secretion, which can cause either hypo- or hyperglycemia. Glycemic control in patients on metformin and sitagliptin may therefore change.
How serious is the interaction between Lanreotide and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting lanreotide or changing the dose, and adjust the antidiabetic regimen as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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