Drug interactions
Cyclosporin + Lanreotide
Severity: Moderate
Cyclosporin and Lanreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatostatin analogues such as lanreotide have been reported to lower cyclosporine absorption and blood concentrations. This may lead to subtherapeutic immunosuppression and a risk of rejection or graft-versus-host disease.
What this interaction means in plain words
Cyclosporin and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Lanreotide belongs to Endocrine.
Why it happens
Lanreotide reduces gastrointestinal absorption of cyclosporine, possibly via effects on gut motility and secretion.
What to do
Monitor cyclosporine trough concentrations after starting or stopping lanreotide and adjust the cyclosporine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Lanreotide
- Lanreotide + Quinidine Major
- Alogliptin-metformin + Lanreotide Moderate
- Canagliflozin-metformin + Lanreotide Moderate
- Dapagliflozin-metformin + Lanreotide Moderate
- Empagliflozin-metformin + Lanreotide Moderate
- Glipizide-metformin + Lanreotide Moderate
Frequently asked questions
Can I take Cyclosporin with Lanreotide?
MediHelp rates the interaction as moderate. Cyclosporin and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatostatin analogues such as lanreotide have been reported to lower cyclosporine absorption and blood concentrations. This may lead to subtherapeutic immunosuppression and a risk of rejection or graft-versus-host disease.
How serious is the interaction between Cyclosporin and Lanreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations after starting or stopping lanreotide and adjust the cyclosporine dose accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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