Drug interactions
Lanreotide + Quinidine
Severity: Major
Lanreotide and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanreotide may reduce hepatic clearance of drugs metabolised by CYP3A4, and quinidine has a narrow therapeutic index. Raised quinidine levels could prolong the QT interval and provoke arrhythmias.
What this interaction means in plain words
Lanreotide and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lanreotide belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Somatostatin analogues may decrease CYP3A4 expression or activity and reduce hepatic metabolic clearance, potentially increasing quinidine concentrations.
What to do
Avoid the combination where possible; if needed, monitor ECG and quinidine concentrations and reduce the quinidine dose as required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lanreotide
- Alogliptin-metformin + Lanreotide Moderate
- Canagliflozin-metformin + Lanreotide Moderate
- Cyclosporin + Lanreotide Moderate
- Dapagliflozin-metformin + Lanreotide Moderate
- Empagliflozin-metformin + Lanreotide Moderate
- Glipizide-metformin + Lanreotide Moderate
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Lanreotide with Quinidine?
MediHelp rates the interaction as major. Lanreotide and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lanreotide may reduce hepatic clearance of drugs metabolised by CYP3A4, and quinidine has a narrow therapeutic index. Raised quinidine levels could prolong the QT interval and provoke arrhythmias.
How serious is the interaction between Lanreotide and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, monitor ECG and quinidine concentrations and reduce the quinidine dose as required.
What other medicines interact with Lanreotide?
MediHelp also lists interactions of Lanreotide with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cyclosporin. The full list is on the Lanreotide page.
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