Drug interactions
Lansoprazole + Liothyronine
Severity: Minor
Lansoprazole and Liothyronine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression with lansoprazole may modestly reduce absorption of oral thyroid hormone, although liothyronine is generally less dependent on gastric acid than levothyroxine. Evidence is inconsistent, but thyroid control could drift in some patients.
What this interaction means in plain words
Lansoprazole and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Liothyronine belongs to Endocrine.
Why it happens
Raised gastric pH may reduce dissolution and absorption of oral thyroid hormone.
What to do
Check TSH and clinical thyroid status after starting or stopping lansoprazole, and adjust the liothyronine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Lansoprazole with Liothyronine?
MediHelp rates the interaction as minor. Lansoprazole and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression with lansoprazole may modestly reduce absorption of oral thyroid hormone, although liothyronine is generally less dependent on gastric acid than levothyroxine. Evidence is inconsistent, but thyroid control could drift in some patients.
How serious is the interaction between Lansoprazole and Liothyronine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH and clinical thyroid status after starting or stopping lansoprazole, and adjust the liothyronine dose if needed.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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