Drug interactions
Lansoprazole + Lisdexamfetamine
Severity: Minor
Lansoprazole and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raised gastric pH from a proton pump inhibitor can slightly speed the appearance of amphetamine in plasma after lisdexamfetamine. Total exposure is essentially unchanged, so the clinical impact is small.
What this interaction means in plain words
Lansoprazole and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Altered gastric pH modestly changes the rate of absorption of amphetamine without changing overall exposure.
What to do
No routine adjustment is needed; review clinical response to the stimulant if the PPI is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lansoprazole and Lisdexamfetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lansoprazole with Lisdexamfetamine?
MediHelp rates the interaction as minor. Lansoprazole and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Raised gastric pH from a proton pump inhibitor can slightly speed the appearance of amphetamine in plasma after lisdexamfetamine. Total exposure is essentially unchanged, so the clinical impact is small.
How serious is the interaction between Lansoprazole and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; review clinical response to the stimulant if the PPI is started or stopped.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
