Drug interactions
Lansoprazole + Posaconazole
Severity: Moderate
Lansoprazole and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Higher gastric pH can reduce absorption of posaconazole oral suspension, lowering antifungal exposure and risking treatment failure. Delayed-release tablets are much less affected. Posaconazole may also slightly raise lansoprazole levels, which is rarely important.
What this interaction means in plain words
Lansoprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lansoprazole belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Reduced gastric acidity impairs dissolution of posaconazole suspension, while posaconazole weakly inhibits CYP3A4 metabolism of lansoprazole.
What to do
Prefer the delayed-release tablet or intravenous posaconazole with a PPI, or avoid the suspension; monitor posaconazole trough levels in prophylaxis or treatment of invasive fungal infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Lansoprazole with Posaconazole?
MediHelp rates the interaction as moderate. Lansoprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Higher gastric pH can reduce absorption of posaconazole oral suspension, lowering antifungal exposure and risking treatment failure. Delayed-release tablets are much less affected. Posaconazole may also slightly raise lansoprazole levels, which is rarely important.
How serious is the interaction between Lansoprazole and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer the delayed-release tablet or intravenous posaconazole with a PPI, or avoid the suspension; monitor posaconazole trough levels in prophylaxis or treatment of invasive fungal infection.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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