Drug interactions
Lansoprazole + Sucralfate
Severity: Minor
Lansoprazole and Sucralfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate may reduce the absorption of lansoprazole when both are taken together, which can weaken acid suppression. The effect is modest and avoidable by separating doses.
What this interaction means in plain words
Lansoprazole and Sucralfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Adsorption of lansoprazole to sucralfate in the gut, decreasing absorption.
What to do
Take lansoprazole at least 30 minutes before sucralfate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sucralfate
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Sucralfate?
MediHelp rates the interaction as minor. Lansoprazole and Sucralfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sucralfate may reduce the absorption of lansoprazole when both are taken together, which can weaken acid suppression. The effect is modest and avoidable by separating doses.
How serious is the interaction between Lansoprazole and Sucralfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take lansoprazole at least 30 minutes before sucralfate.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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