Drug interactions
Lansoprazole + Tucatinib
Severity: Minor
Lansoprazole and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise lansoprazole exposure. Lansoprazole has a wide therapeutic range and other clearance routes, so the effect is usually modest.
What this interaction means in plain words
Lansoprazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, a secondary pathway of lansoprazole metabolism.
What to do
No dose change is generally needed; monitor for PPI adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Lansoprazole with Tucatinib?
MediHelp rates the interaction as minor. Lansoprazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits CYP3A4 and may raise lansoprazole exposure. Lansoprazole has a wide therapeutic range and other clearance routes, so the effect is usually modest.
How serious is the interaction between Lansoprazole and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for PPI adverse effects.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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