Drug interactions
Lapatinib + Lasmiditan
Severity: Moderate
Lapatinib and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro and may raise systemic exposure to BCRP substrates such as lapatinib. Higher lapatinib levels could increase adverse effects such as diarrhea, hepatotoxicity and QT prolongation.
What this interaction means in plain words
Lapatinib and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Lasmiditan belongs to Central Nervous System.
Why it happens
Inhibition of BCRP efflux transport by lasmiditan, potentially increasing lapatinib absorption and exposure.
What to do
Monitor for lapatinib toxicity (diarrhea, liver tests, ECG) if the drugs are used together. Consider an alternative acute migraine therapy if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lapatinib with Lasmiditan?
MediHelp rates the interaction as moderate. Lapatinib and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits BCRP in vitro and may raise systemic exposure to BCRP substrates such as lapatinib. Higher lapatinib levels could increase adverse effects such as diarrhea, hepatotoxicity and QT prolongation.
How serious is the interaction between Lapatinib and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib toxicity (diarrhea, liver tests, ECG) if the drugs are used together. Consider an alternative acute migraine therapy if toxicity develops.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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