Drug interactions
Lapatinib + Nisoldipine
Severity: Moderate
Lapatinib and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib weakly to moderately inhibits CYP3A4, and nisoldipine is a sensitive CYP3A4 substrate with high first-pass metabolism. Higher nisoldipine levels may cause excessive hypotension, dizziness and peripheral edema.
What this interaction means in plain words
Lapatinib and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Nisoldipine belongs to Cardiovascular.
Why it happens
Lapatinib inhibits intestinal and hepatic CYP3A4, reducing nisoldipine first-pass metabolism.
What to do
Monitor blood pressure and heart rate when starting lapatinib, and reduce the nisoldipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Lapatinib with Nisoldipine?
MediHelp rates the interaction as moderate. Lapatinib and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib weakly to moderately inhibits CYP3A4, and nisoldipine is a sensitive CYP3A4 substrate with high first-pass metabolism. Higher nisoldipine levels may cause excessive hypotension, dizziness and peripheral edema.
How serious is the interaction between Lapatinib and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting lapatinib, and reduce the nisoldipine dose if hypotension or edema develops.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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