Drug interactions
Lapatinib + Pomalidomide
Severity: Minor
Lapatinib and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein, and pomalidomide is a P-gp substrate, so its exposure might increase. The expected effect is modest and clinical consequences are uncertain.
What this interaction means in plain words
Lapatinib and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Pomalidomide belongs to Miscellaneous.
Why it happens
P-glycoprotein inhibition by lapatinib may reduce pomalidomide efflux.
What to do
No dose change is generally needed; monitor for pomalidomide adverse effects such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Lapatinib with Pomalidomide?
MediHelp rates the interaction as minor. Lapatinib and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib inhibits P-glycoprotein, and pomalidomide is a P-gp substrate, so its exposure might increase. The expected effect is modest and clinical consequences are uncertain.
How serious is the interaction between Lapatinib and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for pomalidomide adverse effects such as neutropenia.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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