Drug interactions
Lapatinib + Rimegepant
Severity: Moderate
Lapatinib and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein and may raise rimegepant exposure. Rimegepant labeling advises against another dose within 48 hours when it is given with P-gp inhibitors. The result may be more adverse effects such as nausea and hypersensitivity.
What this interaction means in plain words
Lapatinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Rimegepant belongs to Central Nervous System.
Why it happens
Lapatinib inhibits P-gp efflux of rimegepant, which increases its absorption and systemic exposure.
What to do
Avoid taking a second rimegepant dose within 48 hours while on lapatinib. Consider an alternative acute migraine treatment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Rimegepant
Frequently asked questions
Can I take Lapatinib with Rimegepant?
MediHelp rates the interaction as moderate. Lapatinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-glycoprotein and may raise rimegepant exposure. Rimegepant labeling advises against another dose within 48 hours when it is given with P-gp inhibitors. The result may be more adverse effects such as nausea and hypersensitivity.
How serious is the interaction between Lapatinib and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking a second rimegepant dose within 48 hours while on lapatinib. Consider an alternative acute migraine treatment if needed.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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