Drug interactions
Lapatinib + Saxagliptin
Severity: Minor
Lapatinib and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and might raise saxagliptin and its active metabolite exposure. It is not classed as a strong inhibitor, so the effect is probably modest.
What this interaction means in plain words
Lapatinib and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Saxagliptin belongs to Endocrine.
Why it happens
Lapatinib inhibits CYP3A4-mediated metabolism of saxagliptin.
What to do
No routine dose change. Monitor blood glucose and adverse effects of saxagliptin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Saxagliptin?
MediHelp rates the interaction as minor. Lapatinib and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib inhibits CYP3A4 and might raise saxagliptin and its active metabolite exposure. It is not classed as a strong inhibitor, so the effect is probably modest.
How serious is the interaction between Lapatinib and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change. Monitor blood glucose and adverse effects of saxagliptin.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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