Drug interactions
Lapatinib + Sonidegib
Severity: Moderate
Lapatinib and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is metabolized mainly by CYP3A4, and lapatinib is a weak CYP3A4 inhibitor. Raised sonidegib levels could increase the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
What this interaction means in plain words
Lapatinib and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Sonidegib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4, decreasing the clearance of sonidegib.
What to do
Monitor for muscle pain, weakness and creatine kinase elevation. Interrupt or stop sonidegib if significant musculoskeletal toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Lapatinib with Sonidegib?
MediHelp rates the interaction as moderate. Lapatinib and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sonidegib is metabolized mainly by CYP3A4, and lapatinib is a weak CYP3A4 inhibitor. Raised sonidegib levels could increase the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
How serious is the interaction between Lapatinib and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and creatine kinase elevation. Interrupt or stop sonidegib if significant musculoskeletal toxicity develops.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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