Drug interactions
Lapatinib + Tazemetostat
Severity: Moderate
Lapatinib and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a CYP3A4 inhibitor and may increase tazemetostat concentrations. This raises the risk of tazemetostat adverse effects.
What this interaction means in plain words
Lapatinib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 metabolism of tazemetostat.
What to do
Avoid if possible. If necessary, reduce the tazemetostat dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Lapatinib with Tazemetostat?
MediHelp rates the interaction as moderate. Lapatinib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is a CYP3A4 inhibitor and may increase tazemetostat concentrations. This raises the risk of tazemetostat adverse effects.
How serious is the interaction between Lapatinib and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If necessary, reduce the tazemetostat dose per labeling and monitor for toxicity.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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