Drug interactions
Larotrectinib + Methylprednisolone
Severity: Minor
Larotrectinib and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and weak inhibitor, so it could modestly raise exposure to methylprednisolone, a CYP3A4 substrate. The clinical effect is expected to be small.
What this interaction means in plain words
Larotrectinib and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Methylprednisolone belongs to Endocrine.
Why it happens
Possible weak inhibition of CYP3A4-mediated methylprednisolone metabolism by larotrectinib.
What to do
No routine adjustment is needed; watch for signs of corticosteroid excess such as hyperglycemia or fluid retention with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Methylprednisolone?
MediHelp rates the interaction as minor. Larotrectinib and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and weak inhibitor, so it could modestly raise exposure to methylprednisolone, a CYP3A4 substrate. The clinical effect is expected to be small.
How serious is the interaction between Larotrectinib and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for signs of corticosteroid excess such as hyperglycemia or fluid retention with prolonged use.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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