Drug interactions
Larotrectinib + Mirtazapine
Severity: Minor
Larotrectinib and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and weak inhibitor, so it may slightly raise mirtazapine concentrations. A clinically significant effect is unlikely.
What this interaction means in plain words
Larotrectinib and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Mirtazapine belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing mirtazapine clearance.
What to do
No routine adjustment is needed; monitor for increased sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Mirtazapine?
MediHelp rates the interaction as minor. Larotrectinib and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and weak inhibitor, so it may slightly raise mirtazapine concentrations. A clinically significant effect is unlikely.
How serious is the interaction between Larotrectinib and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for increased sedation.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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