Drug interactions
Larotrectinib + Nevirapine
Severity: Minor
Larotrectinib and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak inhibitor of CYP3A4 in vitro, so it could modestly raise nevirapine exposure. Any effect is expected to be small, but nevirapine toxicity such as rash and hepatotoxicity is exposure related. Nevirapine could in turn lower larotrectinib levels through induction.
What this interaction means in plain words
Larotrectinib and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing nevirapine metabolism; the effect is predicted and not well characterized.
What to do
Monitor liver function and skin reactions, and monitor larotrectinib efficacy; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Nevirapine?
MediHelp rates the interaction as minor. Larotrectinib and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak inhibitor of CYP3A4 in vitro, so it could modestly raise nevirapine exposure. Any effect is expected to be small, but nevirapine toxicity such as rash and hepatotoxicity is exposure related. Nevirapine could in turn lower larotrectinib levels through induction.
How serious is the interaction between Larotrectinib and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and skin reactions, and monitor larotrectinib efficacy; no routine dose change is needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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