Drug interactions
Larotrectinib + Oxycodone
Severity: Minor
Larotrectinib and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is metabolized by CYP3A4 and is a weak inhibitor of it in vitro; effect on oxycodone exposure is likely small. Clinically significant oxycodone toxicity is not well documented.
What this interaction means in plain words
Larotrectinib and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Oxycodone belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib may slightly reduce oxycodone clearance.
What to do
No routine dose change is needed; monitor for increased sedation or respiratory depression after starting larotrectinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Oxycodone?
MediHelp rates the interaction as minor. Larotrectinib and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is metabolized by CYP3A4 and is a weak inhibitor of it in vitro; effect on oxycodone exposure is likely small. Clinically significant oxycodone toxicity is not well documented.
How serious is the interaction between Larotrectinib and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for increased sedation or respiratory depression after starting larotrectinib.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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