Drug interactions
Larotrectinib + Palbociclib
Severity: Minor
Larotrectinib and Palbociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory activity, so a small rise in palbociclib exposure is theoretically possible. Clinically relevant effects are not established.
What this interaction means in plain words
Larotrectinib and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Larotrectinib may weakly inhibit CYP3A4, though the effect on palbociclib is unestablished.
What to do
No dose adjustment is needed; monitor blood counts as usual during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Palbociclib
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Palbociclib?
MediHelp rates the interaction as minor. Larotrectinib and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory activity, so a small rise in palbociclib exposure is theoretically possible. Clinically relevant effects are not established.
How serious is the interaction between Larotrectinib and Palbociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood counts as usual during therapy.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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