Drug interactions
Larotrectinib + Ranolazine
Severity: Minor
Larotrectinib and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and may weakly inhibit CYP3A4, so ranolazine concentrations could rise somewhat. The effect is probably modest, but ranolazine's adverse effects are dose-related.
What this interaction means in plain words
Larotrectinib and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reduces ranolazine metabolism.
What to do
No routine dose change is needed. Monitor for dizziness, nausea and QTc prolongation, and reduce the ranolazine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Larotrectinib and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Ranolazine?
MediHelp rates the interaction as minor. Larotrectinib and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and may weakly inhibit CYP3A4, so ranolazine concentrations could rise somewhat. The effect is probably modest, but ranolazine's adverse effects are dose-related.
How serious is the interaction between Larotrectinib and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness, nausea and QTc prolongation, and reduce the ranolazine dose if they occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
