Drug interactions
Larotrectinib + Ropivacaine
Severity: Minor
Larotrectinib and Ropivacaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a substrate of CYP3A4 with only weak inhibitory potential, and ropivacaine relies mainly on CYP1A2. A clinically meaningful rise in ropivacaine levels is unlikely.
What this interaction means in plain words
Larotrectinib and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Ropivacaine belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing a minor ropivacaine clearance pathway.
What to do
No action is routinely required; monitor for toxicity if prolonged infusions are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Ropivacaine?
MediHelp rates the interaction as minor. Larotrectinib and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a substrate of CYP3A4 with only weak inhibitory potential, and ropivacaine relies mainly on CYP1A2. A clinically meaningful rise in ropivacaine levels is unlikely.
How serious is the interaction between Larotrectinib and Ropivacaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is routinely required; monitor for toxicity if prolonged infusions are used.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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