Drug interactions
Larotrectinib + Ruxolitinib
Severity: Minor
Larotrectinib and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor in vitro and could slightly raise ruxolitinib exposure. Clinical significance is likely small.
What this interaction means in plain words
Larotrectinib and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by larotrectinib reduces ruxolitinib metabolism.
What to do
No routine dose change; monitor blood counts and adjust ruxolitinib if cytopenias occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ruxolitinib
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Ruxolitinib?
MediHelp rates the interaction as minor. Larotrectinib and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor in vitro and could slightly raise ruxolitinib exposure. Clinical significance is likely small.
How serious is the interaction between Larotrectinib and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor blood counts and adjust ruxolitinib if cytopenias occur.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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