Drug interactions
Larotrectinib + Temsirolimus
Severity: Minor
Larotrectinib and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with possible weak inhibitory effects, and a meaningful change in temsirolimus exposure is not established. Any interaction is likely small.
What this interaction means in plain words
Larotrectinib and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; not well established.
What to do
No empirical dose change; monitor for temsirolimus toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Temsirolimus?
MediHelp rates the interaction as minor. Larotrectinib and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with possible weak inhibitory effects, and a meaningful change in temsirolimus exposure is not established. Any interaction is likely small.
How serious is the interaction between Larotrectinib and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor for temsirolimus toxicity.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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