Drug interactions
Larotrectinib + Tramadol
Severity: Minor
Larotrectinib and Tramadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate that may modestly inhibit CYP3A4, potentially increasing tramadol exposure. The clinical significance is uncertain but higher tramadol levels could increase opioid and seizure risk.
What this interaction means in plain words
Larotrectinib and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing tramadol metabolism.
What to do
Monitor for increased sedation or other tramadol adverse effects after starting larotrectinib. Adjust the tramadol dose if effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Tramadol?
MediHelp rates the interaction as minor. Larotrectinib and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate that may modestly inhibit CYP3A4, potentially increasing tramadol exposure. The clinical significance is uncertain but higher tramadol levels could increase opioid and seizure risk.
How serious is the interaction between Larotrectinib and Tramadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or other tramadol adverse effects after starting larotrectinib. Adjust the tramadol dose if effects emerge.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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