Drug interactions
Larotrectinib + Trazodone
Severity: Moderate
Larotrectinib and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate that may also inhibit CYP3A4 modestly, and trazodone depends on CYP3A4 for clearance. Trazodone concentrations may increase, raising the risk of sedation, hypotension and QT effects.
What this interaction means in plain words
Larotrectinib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Larotrectinib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP3A4-mediated trazodone metabolism by larotrectinib.
What to do
Use a lower starting dose of trazodone and monitor for sedation, orthostatic hypotension and palpitations. Consider an ECG if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Trazodone?
MediHelp rates the interaction as moderate. Larotrectinib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Larotrectinib is a CYP3A4 substrate that may also inhibit CYP3A4 modestly, and trazodone depends on CYP3A4 for clearance. Trazodone concentrations may increase, raising the risk of sedation, hypotension and QT effects.
How serious is the interaction between Larotrectinib and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower starting dose of trazodone and monitor for sedation, orthostatic hypotension and palpitations. Consider an ECG if other QT-prolonging drugs are present.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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