Drug interactions
Larotrectinib + Trimipramine
Severity: Minor
Larotrectinib and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a substrate and a weak inhibitor of CYP3A4, so it may modestly raise levels of CYP3A4-metabolized drugs. Trimipramine is cleared partly by CYP3A4 along with CYP2C19 and CYP2D6, so the effect is expected to be small.
What this interaction means in plain words
Larotrectinib and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of trimipramine.
What to do
No dose change is usually required. Monitor for increased anticholinergic, sedative and cardiac effects of trimipramine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Trimipramine?
MediHelp rates the interaction as minor. Larotrectinib and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a substrate and a weak inhibitor of CYP3A4, so it may modestly raise levels of CYP3A4-metabolized drugs. Trimipramine is cleared partly by CYP3A4 along with CYP2C19 and CYP2D6, so the effect is expected to be small.
How serious is the interaction between Larotrectinib and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for increased anticholinergic, sedative and cardiac effects of trimipramine.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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