Drug interactions
Larotrectinib + Vortioxetine
Severity: Minor
Larotrectinib and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib has weak CYP3A4 inhibitory potential and vortioxetine relies mainly on CYP2D6, so a meaningful change in exposure is unlikely.
What this interaction means in plain words
Larotrectinib and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Vortioxetine belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; effect is theoretical.
What to do
No dose change is needed. Monitor tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Vortioxetine?
MediHelp rates the interaction as minor. Larotrectinib and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib has weak CYP3A4 inhibitory potential and vortioxetine relies mainly on CYP2D6, so a meaningful change in exposure is unlikely.
How serious is the interaction between Larotrectinib and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor tolerability.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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