Drug interactions
Lasmiditan + Linezolid
Severity: Moderate
Lasmiditan and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a selective 5-HT1F agonist and linezolid is a weak MAO inhibitor with serotonergic liability. Combined use could theoretically raise the risk of serotonin syndrome, though lasmiditan lacks vasoconstrictive 5-HT1B/1D activity.
What this interaction means in plain words
Lasmiditan and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic activity with MAO inhibition by linezolid.
What to do
Watch for mental status change, clonus, tremor, sweating and hyperthermia after lasmiditan doses. Consider an alternative migraine therapy if linezolid is needed and symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Linezolid?
MediHelp rates the interaction as moderate. Lasmiditan and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a selective 5-HT1F agonist and linezolid is a weak MAO inhibitor with serotonergic liability. Combined use could theoretically raise the risk of serotonin syndrome, though lasmiditan lacks vasoconstrictive 5-HT1B/1D activity.
How serious is the interaction between Lasmiditan and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for mental status change, clonus, tremor, sweating and hyperthermia after lasmiditan doses. Consider an alternative migraine therapy if linezolid is needed and symptoms develop.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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