Drug interactions
Lasmiditan + Maprotiline
Severity: Moderate
Lasmiditan and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes sedation, dizziness and cognitive impairment, and maprotiline is also sedating. Combined use may intensify drowsiness and impair psychomotor performance.
What this interaction means in plain words
Lasmiditan and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Counsel patients not to drive or operate machinery for at least 8 hours after lasmiditan. Monitor for excessive sedation and avoid additional CNS depressants including alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Maprotiline?
MediHelp rates the interaction as moderate. Lasmiditan and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes sedation, dizziness and cognitive impairment, and maprotiline is also sedating. Combined use may intensify drowsiness and impair psychomotor performance.
How serious is the interaction between Lasmiditan and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive or operate machinery for at least 8 hours after lasmiditan. Monitor for excessive sedation and avoid additional CNS depressants including alcohol.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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