Drug interactions
Lasmiditan + Metaxalone
Severity: Moderate
Lasmiditan and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence, and metaxalone is also sedating. Together they may increase drowsiness and impair driving ability.
What this interaction means in plain words
Lasmiditan and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of the two drugs.
What to do
Counsel patients not to drive for at least 8 hours after lasmiditan and to be cautious with other sedatives. Monitor for excessive drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Metaxalone?
MediHelp rates the interaction as moderate. Lasmiditan and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence, and metaxalone is also sedating. Together they may increase drowsiness and impair driving ability.
How serious is the interaction between Lasmiditan and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive for at least 8 hours after lasmiditan and to be cautious with other sedatives. Monitor for excessive drowsiness.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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