Drug interactions
Lasmiditan + Milnacipran
Severity: Moderate
Lasmiditan and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan, a 5-HT1F agonist, causes sedation and dizziness, which may add to milnacipran effects. Serotonin syndrome is a theoretical concern, though lasmiditan lacks vasoconstrictive 5-HT1B/1D activity and clinical evidence is limited.
What this interaction means in plain words
Lasmiditan and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Milnacipran belongs to Central Nervous System.
Why it happens
Additive CNS effects and possible additive serotonergic activity.
What to do
Counsel patients not to drive for at least 8 hours after a lasmiditan dose. Monitor for serotonin syndrome symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Milnacipran?
MediHelp rates the interaction as moderate. Lasmiditan and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan, a 5-HT1F agonist, causes sedation and dizziness, which may add to milnacipran effects. Serotonin syndrome is a theoretical concern, though lasmiditan lacks vasoconstrictive 5-HT1B/1D activity and clinical evidence is limited.
How serious is the interaction between Lasmiditan and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive for at least 8 hours after a lasmiditan dose. Monitor for serotonin syndrome symptoms.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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