Drug interactions
Lasmiditan + Mitoxantrone
Severity: Minor
Lasmiditan and Mitoxantrone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro, and mitoxantrone is a BCRP substrate. Higher mitoxantrone exposure is theoretically possible, but this has not been shown clinically, and lasmiditan is used only intermittently.
What this interaction means in plain words
Lasmiditan and Mitoxantrone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Mitoxantrone belongs to Central Nervous System.
Why it happens
Possible inhibition of BCRP efflux by lasmiditan, based on in vitro data.
What to do
No routine change is needed. Monitor blood counts per standard mitoxantrone practice and avoid lasmiditan around infusion days if feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitoxantrone
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Mitoxantrone?
MediHelp rates the interaction as minor. Lasmiditan and Mitoxantrone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits BCRP in vitro, and mitoxantrone is a BCRP substrate. Higher mitoxantrone exposure is theoretically possible, but this has not been shown clinically, and lasmiditan is used only intermittently.
How serious is the interaction between Lasmiditan and Mitoxantrone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor blood counts per standard mitoxantrone practice and avoid lasmiditan around infusion days if feasible.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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