Drug interactions
Lasmiditan + Nadolol
Severity: Moderate
Lasmiditan and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan can lower heart rate, and combining it with a beta-blocker produces an additive reduction in heart rate. This may result in symptomatic bradycardia, dizziness or fatigue in susceptible patients.
What this interaction means in plain words
Lasmiditan and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Nadolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic heart rate lowering from lasmiditan and beta-adrenergic blockade.
What to do
Monitor heart rate and symptoms of bradycardia after lasmiditan doses in patients taking nadolol. Take extra care in patients with baseline bradycardia or conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Nadolol?
MediHelp rates the interaction as moderate. Lasmiditan and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan can lower heart rate, and combining it with a beta-blocker produces an additive reduction in heart rate. This may result in symptomatic bradycardia, dizziness or fatigue in susceptible patients.
How serious is the interaction between Lasmiditan and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms of bradycardia after lasmiditan doses in patients taking nadolol. Take extra care in patients with baseline bradycardia or conduction disease.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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