Drug interactions
Lasmiditan + Nicardipine
Severity: Minor
Lasmiditan and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may increase exposure to P-gp substrates. Nicardipine is not a sensitive P-gp substrate, so any clinical effect is likely small, though additive hypotension or dizziness is possible.
What this interaction means in plain words
Lasmiditan and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Lasmiditan inhibits intestinal P-glycoprotein, potentially increasing absorption of nicardipine.
What to do
No dose change is generally needed; monitor blood pressure and dizziness when starting lasmiditan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Nicardipine?
MediHelp rates the interaction as minor. Lasmiditan and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in vitro and may increase exposure to P-gp substrates. Nicardipine is not a sensitive P-gp substrate, so any clinical effect is likely small, though additive hypotension or dizziness is possible.
How serious is the interaction between Lasmiditan and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor blood pressure and dizziness when starting lasmiditan.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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