Drug interactions
Lasmiditan + Prednisone
Severity: Minor
Lasmiditan and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein and could increase exposure to P-gp substrates. Prednisone is not a clinically important P-gp substrate, so any effect is unlikely to matter.
What this interaction means in plain words
Lasmiditan and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Prednisone belongs to Endocrine.
Why it happens
Lasmiditan inhibits P-glycoprotein efflux, potentially raising absorption of substrates.
What to do
No action is generally needed; monitor for steroid adverse effects if prednisone effects appear enhanced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Prednisone?
MediHelp rates the interaction as minor. Lasmiditan and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits intestinal P-glycoprotein and could increase exposure to P-gp substrates. Prednisone is not a clinically important P-gp substrate, so any effect is unlikely to matter.
How serious is the interaction between Lasmiditan and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; monitor for steroid adverse effects if prednisone effects appear enhanced.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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