Drug interactions
Lasmiditan + Quetiapine
Severity: Moderate
Lasmiditan and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause drowsiness and cognitive slowing. Used together they may produce additive sedation and impair alertness and psychomotor performance. Lasmiditan labeling warns about use with other CNS depressants.
What this interaction means in plain words
Lasmiditan and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel patients to avoid driving or operating machinery for at least 8 hours after lasmiditan. Monitor for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Quetiapine?
MediHelp rates the interaction as moderate. Lasmiditan and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause drowsiness and cognitive slowing. Used together they may produce additive sedation and impair alertness and psychomotor performance. Lasmiditan labeling warns about use with other CNS depressants.
How serious is the interaction between Lasmiditan and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or operating machinery for at least 8 hours after lasmiditan. Monitor for excess sedation.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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